Meet The Little Runaways known as the Vowels - Aline (Armadillo), Eloy (Jaguar), Iris (Agouti), Oscar (Sloth), and Ulysses (Capybara). They are five Brazilian laboratory animals that decide to escape from The Animal Research Center deep in the Brazilian forest. The Animal Research Center is run by the terrible biologist called 'The Doctor!"

The Little Runaways decide to escape the Center and flee into the forest to discover a world that they didn't know existed. The outside world is full of fun, adventure, and freedom, but it can also be scary and dangerous. Danger lurks in the forest, and our five friends need to be on guard while they try and keep one step ahead of The Doctor. Along the way they meet animals that they have never seen before. This is a new world for them and they unprepared for what will happen.

Follow Aline, Eloy, Iris, Oscar, and Ulysses on their adventures. They have to learn to rely on each other and the friendship of the forest animals in order to survive and thrive in their new home.